Structurally symmetric near-infrared fluorophore IRDye78-protein complex enables multimodal cancer imaging
Yang Jiang, Chunhua Zhao, Jacky Lim, Lina Zhao, Ryan Le Tourneau, Qize Zhang, Damien E. Dobson, Suhasini Joshi, Jiadong Pang, Xiaodong Zhang, Suchetan Pal, Chrysafis Andreou, Hanwen Zhang, Moritz F. Kircher, Hans F. Schmitthenner
Abstract
the introduction of α-LA. IRDye78 as a feasible alternative of IRDye800cw currently in clinical phases was proposed with a facile synthesis and fully characterized for the first time. This fluorophore-protein complex with stable radiolabeling should have great potential for clinical translation where it could enable an elegant workflow from preoperative planning to intraoperative deep tissue and high-resolution image-guided resection.
Topics & Concepts
FluorophoreInfraredCancerMolecular imagingChemistryBiophysicsMaterials scienceFluorescenceNanotechnologyMedicineOpticsPhysicsBiologyIn vivoInternal medicineBiotechnologyPhotodynamic Therapy Research Studies