The IL-4/-13 Axis and Its Blocking in the Treatment of Atopic Dermatitis
Georgia Pappa, Dimitrios Sgouros, Konstantinos Theodoropoulos, Αντώνιος Κανελλέας, Evangelia Bozi, Stamatios Gregoriou, Konstantinos Krasagakis, Alexander Katoulis
Abstract
Atopic dermatitis (AD) is a common inflammatory skin disease with a complex pathophysiology, intertwining immune dysregulation, epidermal barrier dysfunction, IgE sensitization, environmental factors and genetic predisposition. It has been recently identified that interleukins -4 and -13 play crucial roles in the type-2-driven inflammation that characterizes AD, contributing to its symptomatology. Novel therapeutic approaches that target Th2 cytokines and their respective pathways have been developed, aiming to optimize the treatment of AD.
Topics & Concepts
MedicineAtopic dermatitisSensitizationGenetic predispositionImmunologyDiseaseImmunoglobulin EComplex diseaseInflammationImmune dysregulationImmune systemPathophysiologySkin barrierDermatologyAntibodyInternal medicineDermatology and Skin DiseasesAllergic Rhinitis and SensitizationAsthma and respiratory diseases