AMPK activation by metformin protects against pulmonary hypertension in rats and relaxes isolated human pulmonary artery
Heba Abdelazeem, Ly Tu, Raphaël Thuillet, Mina Ottaviani, Achraf Boulfrad, Thomas Beck, Amira Senbel, Salma Mani, Yves Castier, Alice Guyard, Alexy Tran-Dinh, Jamel El‐Benna, Dan Longrois, Adam M. Silverstein, Christophe Guignabert, Xavier Norel
Topics & Concepts
AMPKMetforminEnosPulmonary hypertensionHypoxic pulmonary vasoconstrictionInternal medicineProstacyclinMedicineEndocrinologyProtein kinase AAMP-activated protein kinaseVasoconstrictionEndotheliumPulmonary arteryPharmacologyNitric oxideNitric oxide synthaseChemistryPhosphorylationDiabetes mellitusBiochemistryPulmonary Hypertension Research and TreatmentsCardiovascular Function and Risk FactorsNitric Oxide and Endothelin Effects