Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome
Hisaya Kato, Yoshiro Maezawa, Naoya Takayama, Yasuo Ouchi, Hiyori Kaneko, Daisuke Kinoshita, Aki Takada‐Watanabe, Motohiko Oshima, Masaya Koshizaka, Hideyuki Ogata, Yoshitaka Kubota, Nobuyuki Mitsukawa, Koji Eto, Atsushi Iwama, Koutaro Yokote
Abstract
. On the other hand, the osteogenic potential was mutually maintained and comparable in the foot and trunk fibroblasts. These distinct phenotypes in the foot and trunk fibroblasts are consistent with the clinical symptoms of WS and may partially explain the underlying mechanism of this disease phenotype.
Topics & Concepts
ProgeriaPhenotypeWerner syndromeGeneticsBiologyMedicineGeneRNAHelicaseNuclear Structure and FunctionMicrotubule and mitosis dynamicsGenetic Neurodegenerative Diseases