CB2 Agonist (AM1241) Improving Effect on Ovalbumin-Induced Asthma in Rats.
Ali Parlar, Seyfullah Oktay Arslan, Javad Tavakoli, Susan Maziarfar, Jalil Fallah Mehrabadi
Abstract
< 0.05) in BALF or serum or lung tissue. But CB2-antagonist treatment prevented the protective effect of CB2 agonist. The aim of this study was to study the role of the CB2 receptor in the OVA induced asthma model, to improve inflammatory hypersensitivity, and edema in the rats. The results suggested that CB2 agonist administration to OVA induced asthmatic rats via anti-asthmatic potential through inhibition of parameters such as IgE, IL-4, TNF-α, microvascular escape, and oxidative stress.
Topics & Concepts
OvalbuminAgonistMedicineBronchoalveolar lavageAsthmaImmunoglobulin ECannabinoid receptor type 2AntagonistReceptorEdemaPharmacologyImmunologyInternal medicineEndocrinologyLungCannabinoid receptorImmune systemAntibodyCannabis and Cannabinoid ResearchNeuroscience of respiration and sleepSleep and Wakefulness Research