BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2
Avi J. Samelson, Quang Dinh Tran, Rémy Robinot, Lucia Carrau, Veronica V. Rezelj, Alice Mac Kain, Merissa Chen, Gokul N. Ramadoss, Xiaoyan Guo, Shion A. Lim, Irene Lui, James K. Nuñez, Sarah J. Rockwood, Jianhui Wang, Na Liu, Jared Carlson-Stevermer, Jennifer Oki, Travis Maures, Kevin Holden, Jonathan S. Weissman, James A. Wells, Bruce R. Conklin, Benjamin R. TenOever, Lisa A. Chakrabarti, Marco Vignuzzi, Ruilin Tian, Martin Kampmann
Topics & Concepts
BiologyDruggabilityCell biologyTranscription factorTranscription (linguistics)ReceptorCellInterferonGeneViral replicationPlasma protein bindingRegulatorHEK 293 cellsEndogenyCancer researchRegulation of gene expressionDNA-binding proteinGene expressionSignal transductionCell cultureVirologyBasic helix-loop-helix leucine zipper transcription factorsProtein Degradation and InhibitorsChromatin Remodeling and CancerGenomics and Chromatin Dynamics