Synthesis and Application of Amino‐1<i>H</i>‐1,2,3‐triazolium Salts
Daiya Kase, Tsuyoshi Takada, Nanami Tsuji, Takuya Mitsuhashi, Ryosuke Haraguchi
Abstract
Abstract Herein, we developed a fluoride‐mediated nucleophilic aromatic amination of chloro‐1 H ‐1,2,3‐triazolium salts. Various functional groups were tolerated in this reaction, which enabled the synthesis of functionalized amino‐1 H ‐1,2,3‐triazolium salts. In addition, we investigated the catalytic properties of triazolium‐based N‐heterocyclic imines (NHIs) for cyanosilylation of ketones. The substituent was found to play a crucial role for inducing high catalytic activity.
Topics & Concepts
ChemistrySubstituentAminationCatalysisNucleophileFluorideOrganic chemistryMedicinal chemistryCombinatorial chemistryInorganic chemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsFluorine in Organic Chemistry