Impact of Prostate Health Index Results for Prediction of Biopsy Grade Reclassification During Active Surveillance
Christopher P. Filson, Kehao Zhu, Yijian Huang, Yingye Zheng, Lisa F. Newcomb, Sierra Williams, James D. Brooks, Peter R. Carroll, Atreya Dash, William J. Ellis, Martin Gleave, Michael A. Liss, Frances M. Martin, Jesse K. McKenney, Todd M. Morgan, Andrew A. Wagner, Lori J. Sokoll, Martin G. Sanda, Daniel W. Chan, Daniel W. Lin
Abstract
PURPOSE: We assessed whether Prostate Health Index results improve prediction of grade reclassification for men on active surveillance. METHODS AND MATERIALS: for specificity and sensitivity were evaluated. RESULTS: among the biopsy cohort overall (ΔAUC 0.007, 95% CI -0.007-0.020). CONCLUSIONS: Among active surveillance patients, using Prostate Health Index with clinical data modestly improved prediction of grade reclassification on confirmatory biopsy and did not improve prediction on subsequent biopsies.