Synthesis of tetrasubstituted alkenyl nitriles <i>via</i> cyanocarbene addition of [1.1.1]propellane
Xinpeng Jiang, Zicong Zheng, Yan Gao, Deyou Lan, Wenhao Xu, Wang Zhang, Guofei Chen
Abstract
Methylenecyclobutane containing tetrasubstituted alkenyl nitriles were synthesized via strain-release driven cyanocarbene addition reaction of [1.1.1]propellane under metal-free and mild conditions.
Topics & Concepts
PropellaneChemistryMedicinal chemistryOrganic chemistryBicyclic moleculeCatalytic Cross-Coupling ReactionsSynthetic Organic Chemistry MethodsCyclopropane Reaction Mechanisms