Impact of library input on the hit discovery rate in DNA-encoded chemical library selections
Sara Puglioli, Sebastian Oehler, Luca Prati, Jörg Scheuermann, Gabriele Bassi, Samuele Cazzamalli, Dario Neri, Nicholas Favalli
Abstract
copies of each library member is required for the confident identification of nanomolar hits, using generally applicable methodologies.
Topics & Concepts
Computational biologyDNAChemical libraryDrug discoveryComputer scienceBiologyGeneticsBioinformaticsSmall moleculeMonoclonal and Polyclonal Antibodies ResearchRNA and protein synthesis mechanismsAdvanced biosensing and bioanalysis techniques