Tubular Elabela-APJ axis attenuates ischemia-reperfusion induced acute kidney injury and the following AKI-CKD transition by protecting renal microcirculation
Mingrui Xiong, Hong Chen, Yu Fan, Muchuan Jin, Dong Yang, Yuchen Chen, Yu Zhang, Robert B. Petersen, Huabo Su, Anlin Peng, Cong‐Yi Wang, Ling Zheng, Kun Huang
Abstract
An endogenous tubular ELA-APJ axis regulates renal microvascular blood flow that plays a pivotal role in I/R-induced AKI. Furthermore, improving renal blood flow by inhibiting ARG2 and activating PGE2 is an effective treatment for AKI and prevents the subsequent AKI-CKD transition.
Topics & Concepts
Acute kidney injuryMedicineReperfusion injuryKidneyMicrocirculationRenal blood flowKidney diseaseIschemiaPharmacologyRenal ischemiaPeritubular capillariesInternal medicineEndocrinologyApelin-related biomedical researchCardiovascular, Neuropeptides, and Oxidative Stress ResearchParaoxonase enzyme and polymorphisms