Regulation of autophagosome biogenesis and mitochondrial bioenergetics by the cholesterol transport protein GRAMD1C
Chara Charsou, Matthew Yoke Wui Ng, Anne Simonsen
Abstract
ATG: autophagy related; ccRCC: clear cell renal cell carcinoma; ER: endoplasmic reticulum; GRAM: glucosyltransferases, RAB-like GTPase activators and myotubularins; GRAMD: GRAM domain containing; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MCBD: methyl-cyclodextrin; MTOR: mechanistic target of rapamycin kinase; VASt: VAD1 analog of StAR-related lipid transfer.
Topics & Concepts
AutophagyBiologyAutophagosomeCell biologyEndoplasmic reticulumBiochemistryApoptosisAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseCellular transport and secretion