Promising Non-cytotoxic Monosubstituted Chalcones to Target Monoamine Oxidase-B
L.G. Iacovino, Luca Pinzi, Giorgio Facchetti, Beatrice Bortolini, Michael S. Christodoulou, Claudia Binda, Giulio Rastelli, Isabella Rimoldi, Daniele Passarella, Maria Luisa Di Paolo, Lisa Dalla Via
Abstract
as a chalcone derivative that is worth consideration for the development of novel MAO-B-selective inhibitors for the treatment of neurodegenerative diseases.
Topics & Concepts
ChalconeCytotoxicityMonoamine oxidaseChemistryMonoamine oxidase BStereochemistryDocking (animal)Monoamine oxidase AViability assayPharmacophoreCell cultureEnzymeApoptosisCombinatorial chemistryBiochemistryIn vitroMedicineBiologyGeneticsNursingSynthesis and Biological EvaluationGarlic and Onion StudiesSynthesis and biological activity