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Discovery of the PARP (poly ADP-ribose polymerase) inhibitor 2-(1-(4,4-difluorocyclohexyl)piperidin-4-yl)-1H-benzo[d]imidazole-4-carboxamide for the treatment of cancer

Lin Tang, Weibin Wu, Cunlong Zhang, Zhichao Shi, Dawei Chen, Xin Zhai, Yuyang Jiang

2021Bioorganic Chemistry18 citationsDOI

Topics & Concepts

ChemistryBenzimidazoleCarboxamidePARP1CytotoxicityPoly ADP ribose polymeraseADMEStereochemistryImidazoleMicrosomeIC50Cancer cellIn vitroPharmacologyBiochemistryCancerPolymeraseEnzymeOrganic chemistryInternal medicineMedicinePARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure AnalysisLow-power high-performance VLSI design
Discovery of the PARP (poly ADP-ribose polymerase) inhibitor 2-(1-(4,4-difluorocyclohexyl)piperidin-4-yl)-1H-benzo[d]imidazole-4-carboxamide for the treatment of cancer | Litcius