Trimetazidine attenuates Ischemia/Reperfusion-Induced myocardial ferroptosis by modulating the Sirt3/Nrf2-GSH system and reducing Oxidative/Nitrative stress
Mingyue Tan, Yunfei Yin, Weixiang Chen, Jun Zhang, Yifeng Jin, Yue Zhang, Lei Zhang, Tingbo Jiang, Bin Jiang, Hongxia Li
Topics & Concepts
SIRT3GPX4Oxidative stressPharmacologyDownregulation and upregulationIn vivoTrimetazidineGlutathioneCardioprotectionChemistryLipid peroxidationCell biologyProgrammed cell deathIschemiaMedicineApoptosisBiologyAcetylationSirtuinBiochemistrySuperoxide dismutaseInternal medicineEnzymeGlutathione peroxidaseGeneBiotechnologyCancer-related molecular mechanisms researchFerroptosis and cancer prognosisCircular RNAs in diseases