A computational method for immune repertoire mining that identifies novel binders from different clonotypes, demonstrated by identifying anti-pertussis toxoid antibodies
Eve Richardson, Jacob D. Galson, Paul Kellam, Dominic F. Kelly, Sarah E. Smith, Anne Palser, Simon J. Watson, Charlotte M. Deane
Abstract
: BCR: B-cell receptor; CDR: complementarity-determining region; PTx: pertussis toxoid.
Topics & Concepts
ParatopeEpitopeAntibodyBiologyAntibody RepertoireAntigenComputational biologyComplementarity determining regionImmunologyIdiotypeVirologyImmunoglobulin light chainMonoclonal antibodyMonoclonal and Polyclonal Antibodies ResearchT-cell and B-cell Immunologyvaccines and immunoinformatics approaches