Cryo-EM structures reveal two allosteric inhibition modes of PI3KαH1047R involving a re-shaping of the activation loop
Xiuliang Huang, Kailiang Wang, Jing Han, Xiumei Chen, Zhenglin Wang, Tianlun Wu, Bo Yu, Feng Zhao, Xinjuan Wang, Huijuan Li, Zhi Xie, Xiaotian Zhu, Wenge Zhong, Xiaoming Ren
Topics & Concepts
Allosteric regulationChemistryPI3K/AKT/mTOR pathwayEnzymeBiochemistrySignal transductionPI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and CancerBiochemical and Molecular Research