Using the Ni-[(benzylprolyl)amino]benzophenone complex in the Glaser reaction for the synthesis of bis α-amino acids
Anna F. Mkrtchyan, Liana A. Hayriyan, Ani J. Karapetyan, Anna S. Tovmasyan, Avetis Tsaturyan, Victor N. Khrustalev, Victor I. Maleev, Ashot S. Saghyan
Abstract
Enantiomerically enriched (<italic>S</italic>)-α-amino acids were obtained. As the initial complex, the Schiff base Ni(<sc>ii</sc>) complexes were used. The target Ni(<sc>ii</sc>) complexes were disassembled and the amino acids were isolated with excellent enantioselectivities.
Topics & Concepts
ChemistryBenzophenoneSchiff baseAmino acidStereochemistryBase (topology)Medicinal chemistryOrganic chemistryBiochemistryMathematical analysisMathematicsChemical Synthesis and AnalysisAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and Catalysis