14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban
Julia Menzel, Daniel Kownatzki-Danger, Sergiy Tokar, Alice Ballone, Kirsten Unthan‐Fechner, Markus Kilisch, Christof Lenz, Henning Urlaub, Mattia Mori, Christian Ottmann, Michael J. Shattock, Stephan E. Lehnart, Blanche Schwappach
Abstract
handling, our results identify 14-3-3 binding to PLN as a contractility-augmenting mechanism.
Topics & Concepts
PhospholambanAction (physics)KinaseCell biologyChemistryProtein kinase AState (computer science)BiologyBiophysicsComputer sciencePhosphorylationPhysicsQuantum mechanicsAlgorithm14-3-3 protein interactionsUbiquitin and proteasome pathwaysMicrotubule and mitosis dynamics