Cascades of Evolved Enzymes for the Synthesis of Complex Molecules
Katrin Rosenthal, Uwe T. Bornscheuer, Stephan Lütz
Abstract
Abstract Thanks to advances in enzyme discovery and protein engineering combined with the development of enzymatic multistep reaction cascades, new efficient routes for drug synthesis have been created that are superior to chemical syntheses. This supports the goal of the chemical and pharmaceutical industries to move to more sustainable and environmentally friendly processes. Recently described outstanding examples include the biocatalytic cascade syntheses of the cyclic dinucleotide MK‐1454, molnupiravir, and islatravir, as well as the efficient fixation of CO 2 to make starch using an artificial enzyme cascade.
Topics & Concepts
CascadeBiochemical engineeringDrug discoveryChemistryCombinatorial chemistryEnzymeEnvironmentally friendlyProtein engineeringCascade reactionChemical synthesisSynthetic biologyNanotechnologyComputational biologyComputer scienceBiochemistryMaterials scienceEngineeringBiologyCatalysisChromatographyIn vitroEcologyEnzyme Catalysis and ImmobilizationClick Chemistry and ApplicationsCyclopropane Reaction Mechanisms