A neural substrate of compulsive alcohol use
Esi Domi, Li Xu, Sanne Toivainen, Anton Nordeman, Francesco Gobbo, Marco Vènniro, Yavin Shaham, Robert O. Messing, Esther Visser, Michel C. van den Oever, Lovisa Holm, Estelle Barbier, Eric Augier, Markus Heilig
Abstract
inhibitory neurons in the lateral subdivision of CeA (CeL) accounted for ~75% of variance in punishment-resistant alcohol taking. Activity-dependent tagging, followed by chemogenetic inhibition of neurons activated during punishment-resistant self-administration, suppressed alcohol taking, as did a virally mediated shRNA knockdown of PKCδ in CeA. These findings identify a previously unknown mechanism for a core element of alcohol addiction and point to a novel candidate therapeutic target.
Topics & Concepts
Neural substrateAlcoholSubstrate (aquarium)NeuroscienceMedicineComputer sciencePsychologyBiologyBiochemistryEcologyCognitionNeurotransmitter Receptor Influence on BehaviorEating Disorders and BehaviorsSubstance Abuse Treatment and Outcomes