Cartilage Oligomeric Matrix Protein promotes epithelial-mesenchymal transition by interacting with Transgelin in Colorectal Cancer
Weilong Zhong, Huiqin Hou, Tianyu Liu, Shuai Su, Xiaonan Xi, Yusheng Liao, Runxiang Xie, Ge Jin, Xiang Liu, Lanping Zhu, Hongxia Zhang, Xueli Song, Cheng Yang, Tao Sun, Hailong Cao, Bangmao Wang
Abstract
This study illustrated the role of COMP in EMT and suggested that COMP/TAGLN may be a potential tumor therapeutic target. Chrysin exhibits obvious antitumor effects. This work provides a preliminary antitumor therapy to target COMP or its interaction protein to inhibit EMT.
Topics & Concepts
Colorectal cancerEpithelial–mesenchymal transitionCartilageCartilage oligomeric matrix proteinBone matrixMatrix (chemical analysis)Cell biologyCancer researchExtracellular matrixMesenchymal stem cellChemistryCancerMedicinePathologyBiologyAnatomyInternal medicineMetastasisOsteoarthritisChromatographyAlternative medicineCancer-related molecular mechanisms researchCancer-related gene regulationCancer, Lipids, and Metabolism