Achieving high singlet-oxygen generation by applying the heavy-atom effect to thermally activated delayed fluorescent materials
Yafang Xiao, Jia‐Xiong Chen, Wen‐Cheng Chen, Xiuli Zheng, Chen Cao, Jihua Tan, Xiao Cui, Zhanxiang Yuan, Shaomin Ji, Guihong Lu, Weimin Liu, Pengfei Wang, Shengliang Li, Chun‐Sing Lee
Abstract
A bromine-substituted thermally activated delayed fluorescent (TADF) molecule AQCzBr2 is designed with both small singlet-triplet splitting (ΔEST) and increased spin-orbit coupling (SOC) to boost intersystem crossing (ISC) for singlet oxygen generation. AQCzBr2 nanoparticles (NPs) demonstrate high productivity of singlet oxygen generation (ΦΔ = 0.91) which allows highly efficient photodynamic therapy toward cancer cells.
Topics & Concepts
Singlet oxygenFluorescenceAtom (system on chip)PhotochemistryOxygenOxygen atomMaterials scienceOptoelectronicsChemistryMoleculeOpticsPhysicsOrganic chemistryComputer scienceEmbedded systemPerovskite Materials and ApplicationsOrganic Light-Emitting Diodes ResearchNanoplatforms for cancer theranostics