A common SNP risk variant MT1-MMP causative for Dupuytren's disease has a specific defect in collagenolytic activity
Yoshifumi Itoh, Michael Ng, Akira Wiberg, Katsuaki Inoue, Narumi Hirata, Katiúcia Batista Silva Paiva, Noriko Ito, Kim E. Dzobo, Nanami Sato, Valentina Gifford, Yasuyuki Fujita, Masaki Inada, Dominic Furniss
Topics & Concepts
AllelePhenotypeMyofibroblastBiologyGenotypePopulationMatrix metalloproteinaseGeneticsMolecular biologyPathologyFibrosisGeneMedicineEnvironmental healthDupuytren's Contracture and TreatmentsNail Diseases and TreatmentsSurgical Sutures and Adhesives