Microwave-assisted synthesis, molecular docking studies of 1,2,3-triazole-based carbazole derivatives as antimicrobial, antioxidant and anticancer agents
D. Ashok, Gugulothu Thara, Bhukya Kiran Kumar, Srinivas Gundu, Ravinder Dharavath, Vishnu Thumma, M. Sarasija, Sushmitha Bujji
Abstract
C NMR, mass, and IR spectroscopy and evaluated for their antimicrobial, antioxidant and anticancer activities. Among the synthesized compounds, 4d, 4j, 4n, 4p, 4s and 4r were found to exhibit good antimicrobial, antioxidant, anticancer activities. The biological activity of the synthesized compounds was further supplemented by molecular docking studies against the target receptors caspase-3 and 17-beta-hydroxy steroid dehydrogenase type 1, revealing that the reported structures best fit into the active site pocket of the target molecules.
Topics & Concepts
ChemistryAntimicrobialCycloadditionClick chemistryCombinatorial chemistryDocking (animal)1,2,3-TriazoleCarbazoleAntioxidantIndole testPyrazoleTriazoleStereochemistryOrganic chemistryCatalysisNursingMedicineClick Chemistry and ApplicationsSynthesis and biological activitySynthesis and Biological Evaluation