Endocannabinoid signaling in astrocytes
Abel Eraso‐Pichot, Sandrine Pouvreau, Alexandre Oliveira-Pinto, Paula Gómez-Sotres, Urszula Skupio, Giovanni Marsicano
Abstract
Abstract The study of the astrocytic contribution to brain functions has been growing in popularity in the neuroscience field. In the last years, and especially since the demonstration of the involvement of astrocytes in synaptic functions, the astrocyte field has revealed multiple functions of these cells that seemed inconceivable not long ago. In parallel, cannabinoid investigation has also identified different ways by which cannabinoids are able to interact with these cells, modify their functions, alter their communication with neurons and impact behavior. In this review, we will describe the expression of different endocannabinoid system members in astrocytes. Moreover, we will relate the latest findings regarding cannabinoid modulation of some of the most relevant astroglial functions, namely calcium (Ca 2+ ) dynamics, gliotransmission, metabolism, and inflammation.