Nonsegmented Negative-Sense RNA Viruses Utilize <i>N</i> <sup>6</sup> -Methyladenosine (m <sup>6</sup> A) as a Common Strategy To Evade Host Innate Immunity
Mijia Lu, Miaoge Xue, Hai-Tao Wang, Elizabeth L. Kairis, Sadeem Ahmad, Jiangbo Wei, Zijie Zhang, Qinzhe Liu, Yuexiu Zhang, Youling Gao, Dominique Garcin, Mark E. Peeples, Amit Sharma, Sun Hur, Chuan He, Jiànróng Lǐ
Abstract
A methylation as a common mechanism for many NNS RNA viruses to evade host innate immunity, this study discovered a novel strategy to enhance type I interferon responses, which may have important applications in vaccine development, as robust innate immunity will likely promote the subsequent adaptive immunity.
Topics & Concepts
BiologyRNAInnate immune systemSense (electronics)VirologyViral replicationImmunityHost (biology)Replication (statistics)GeneRNA virusGeneticsVirusImmune systemElectrical engineeringEngineeringRNA modifications and cancerViral Infections and Immunology ResearchViral gastroenteritis research and epidemiology