Improvement of Ocular Efficacy of Levofloxacin by Bioadhesive Chitosan Coated PLGA Nanoparticles: Box-behnken Design, <i>In-vitro</i> Characterization, Antibacterial Evaluation and Scintigraphy Study.
Ameeduzzafar Zafar, Nazia Khan, Nabil K. Alruwaili, Syed Nasir Abbas Bukhari, Bader Alsuwayt, Muhammad Afzal, Sana Akhter, Mohd Yasir, Mohammed Elmowafy, Khaled Shalaby, Asgar Ali
Abstract
0.05) higher permeation as compared to marketed formulation. Formulation was nonirritant and possessed good antibacterial activity. Gamma Scintigraphy showed slow drainage compared to drug solution, indicating reduction in nasolachrymal drainage. The Gamma Scintigraphy study indicated the CS coated PLGA-NPs have high corneal residence time as compared to drug solution. So, it is revealed that LFV-CS-PLGA-NPs increase the drug concentration over ocular tissue and potential usefulness for sustained drug delivery.
Topics & Concepts
PLGAChitosanBioadhesiveMucoadhesionPolyvinyl alcoholParticle sizeNanoparticlePermeationNuclear chemistryBox–Behnken designChromatographyMaterials scienceChemistryDrug deliveryBiomedical engineeringNanotechnologyResponse surface methodologyMedicineOrganic chemistryComposite materialMembranePhysical chemistryBiochemistryAdvanced Drug Delivery SystemsOcular Surface and Contact LensAdvancements in Transdermal Drug Delivery