Advances in the study of acetaminophen-induced liver injury
Xinghui Li, Jiaqi Ni, Li Chen
Abstract
Acetaminophen (APAP) overdose is a significant cause of drug-induced liver injury and acute liver failure. The diagnosis, screening, and management of APAP-induced liver injury (AILI) is challenging because of the complex mechanisms involved. Starting from the current studies on the mechanisms of AILI, this review focuses on novel findings in the field of diagnosis, screening, and management of AILI. It highlights the current issues that need to be addressed. This review is supposed to summarize the recent research progress and make recommendations for future research.
Topics & Concepts
AcetaminophenLiver injuryMedicineLiver failureacetaminophen overdoseIntensive care medicineDrugPharmacologyInternal medicineBiologyAcetylcysteineAntioxidantBiochemistryDrug-Induced Hepatotoxicity and ProtectionPharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms