Isolation and Characterization of Human Monoclonal Antibodies to Pneumococcal Capsular Polysaccharide 3
Rachelle Babb, Christopher R. Doyle, Liise-anne Pirofski
Abstract
Despite the global success of vaccination with pneumococcal conjugate vaccines, serotype 3 (ST3) pneumococcus remains a leading cause of morbidity and mortality. In comparison to other vaccine-included serotypes, the ST3 pneumococcal capsular polysaccharide (PPS3) induces a weaker opsonophagocytic response, which is considered a correlate of vaccine efficacy.
Topics & Concepts
Streptococcus pneumoniaeSerotypeBiologyMicrobiologyAntibodyPneumococcal infectionsMonoclonal antibodyAgglutination (biology)ImmunologyConjugate vaccinePneumococcal conjugate vaccineVirologyStreptococcaceaeColonizationImmune systemImmunizationPolysaccharidePneumococcal vaccinePneumococcal diseaseStreptococcusStreptococcus agalactiaePneumococcal polysaccharide vaccineAntigenBacterial capsuleVaccinationIsolation (microbiology)BacteriaStaphylococcus aureusImmunoglobulin GGenePneumonia and Respiratory InfectionsInhalation and Respiratory Drug DeliveryInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis