Potential applications of macrophages in cancer immunotherapy
Maryam Sadri, Sahel Heidari, Arezoo Faridzadeh, Mona Roozbehani, Shirin Toosi, Reihaneh Alsadat Mahmoudian, Akram Hoseinzadeh, Mohammad Taha Salmani Fard, Fahimeh Lavi Arab, Soheil Rahmani Fard, Fatemeh Faraji
Abstract
Immunotherapy has improved cancer treatment based on investigations of tumor immune escape. Manipulation of the immune system stimulates antitumor immune responses and blocks tumor immune escape routes. Genetically adoptive cell therapy, such as T cells, has yielded promising results for hematologic malignancies, but their application to solid tumors has been challenging. Macrophages have a wide broad of capabilities in regulating immune responses, homeostasis, and tissue development, as well as the ability to phagocyte, present antigens, and infiltrate the tumor microenvironment (TME). Given the importance of macrophages in cancer development, they could serve as novel tool for tumor treatment. Therefore, macrophages are used in different formats for direct and indirect targeting of tumor cells. This review summarized the available data on the various applications of macrophages in cancer immunotherapy.