New bioactive 5-arylcarboximidamidopyrazolo[3,4-c]pyridines: Synthesis, cytotoxic activity, mechanistic investigation and structure-activity relationships
Athanasios Papastathopoulos, Nikolaos Lougiakis, Ioannis K. Kostakis, Panagiotis Marakos, Nicole Pouli, Harris Pratsinis, Dimitris Kletsas
Topics & Concepts
ChemistryMAPK/ERK pathwayCytotoxicityPhosphorylationCytotoxic T cellProtein kinase Bp38 mitogen-activated protein kinasesApoptosisCell cultureCell cycleCell growthMode of actionStructure–activity relationshipCell cycle checkpointBiochemistryStereochemistryIn vitroBiologyGeneticsSynthesis and biological activityQuinazolinone synthesis and applicationsSynthesis and Characterization of Heterocyclic Compounds