Reciprocal interactions between malignant cells and macrophages enhance cancer stemness and M2 polarization in HBV-associated hepatocellular carcinoma
Qingyang Zhang, Yu‐Man Tsui, Vanilla Xin Zhang, Anna Jingyi Lu, Joyce Man‐Fong Lee, Eva Lee, Gary Cheuk-Hang Cheung, Po-Man Li, Elaine Tin-Yan Cheung, Nam-Hung Chia, Irene Lo, Albert Chan, Tan To Cheung, Irene Oi‐Lin Ng, Daniel Wai‐Hung Ho
Abstract
Our study highlighted the critical role of stemness-related cancer cell populations in driving an immunosuppressive tumor microenvironment and identified the S100A11 gene as a key mediator for stemness maintenance in HCC. Moreover, our study provides support that the maintenance of cancer stemness is more attributed to M2 polarization than the recruitment of the TAMs.
Topics & Concepts
Cancer researchCancer stem cellTumor microenvironmentBiologyStem cellFlow cytometryCellCell cultureImmunologyCell biologyTumor cellsGeneticsImmune cells in cancerSingle-cell and spatial transcriptomicsCancer Cells and Metastasis