Synthetic mucus barrier arrays as a nanoparticle formulation screening platform
Harry Zou, Allison Boboltz, Yahya Cheema, Daniel Song, Devorah Cahn, Gregg A. Duncan
Abstract
-acetyl cysteine (NAC), we found TCEP significantly improved nanoparticle penetration through a disease-like synthetic mucus barrier. Overall, our results establish a new high-throughput screening approach using synthetic mucus barrier arrays to identify promising nanoparticle formulation strategies for drug delivery to mucosal tissues.
Topics & Concepts
MucusNanoparticleNanotechnologyMaterials scienceComputer scienceBiologyEcologyAdvanced Drug Delivery SystemsRNA Interference and Gene DeliveryProtein purification and stability