Soluble α-klotho anchors TRPV5 to the distal tubular cell membrane independent of FGFR1 by binding TRPV5 and galectin-1 simultaneously
Jinho Lee, Kyung Don Ju, Hyo Jin Kim, Bodokhsuren Tsogbadrakh, Hyunjin Ryu, Eunjeong Kang, Minjung Kang, Jaeseok Yang, Hee Gyung Kang, Curie Ahn, Kook‐Hwan Oh
Abstract
Soluble α-klotho anchors transient receptor potential vanilloid type 5 (TRPV5) on the apical membrane of the distal tubule by binding both TRPV5 and a membrane-abundant protein, galectin-1. This newly discovered mechanism works even when fibroblast growth factor (FGF)23 signaling is inhibited by treatment with FGF receptor type 1 inhibitor. Therefore, we identified how soluble α-klotho increases TRPV5 without FGF23. We confirmed this mechanism by observing that soluble α-klotho fails to enhance TRPV5 when both FGF receptor type 1 and galectin-1 are inhibited.
Topics & Concepts
Transient receptor potential channelFibroblast growth factorKlothoCell biologyReceptorChemistryEndocrinologyInternal medicineBiologyBiochemistryMedicineKidneyGalectins and Cancer BiologyWnt/β-catenin signaling in development and cancerMagnesium in Health and Disease