Sphingolipid-Containing Outer Membrane Vesicles Serve as a Delivery Vehicle To Limit Macrophage Immune Response to Porphyromonas gingivalis
Fernanda Regina Godoy Rocha, Gregory Ottenberg, Zavier G. Eure, Mary E. Davey, Frank C. Gibson
Abstract
Sphingolipids (SLs) are essential structural components of mammalian cell membranes. Our group recently determined that the oral anaerobe Porphyromonas gingivalis delivers its SLs to host cells and that the ability of P. gingivalis to synthesize SLs limits the elicited host inflammatory response during cellular infection.
Topics & Concepts
Porphyromonas gingivalisBiologyBacterial outer membraneToll-like receptorTLR2LipopolysaccharideMicrobiologyImmune systemTumor necrosis factor alphaTLR4MacrophageTRIFCell biologyInnate immune systemImmunologyBacteriaIn vitroBiochemistryEscherichia coliGeneticsGeneOral microbiology and periodontitis researchBacterial Infections and VaccinesImmune Response and Inflammation