Trends in Population Dynamics of<i>Escherichia coli</i>Sequence Type 131, Calgary, Alberta, Canada, 2006–20161
Gisele Peirano, Tarah Lynch, Yasufumi Matsumara, Diego B. Nóbrega, Thomas J. Finn, Rebekah DeVinney, Johann Pitout
Abstract
E scherichia coli sequence type (ST) 131 is the quint- essential example of a successful, global, antimicrobial-resistant, high-risk clone among human bacteria (1,2). Currently, ST131 is the most common global extraintestinal pathogenic E. coli (ExPEC) clone; up to 30% of all ExPEC, 60%-90% of fluoroquinolone-resistant ExPEC, and 40%-80% of ExPEC with extended-spectrum -lactamases [ESBLs] belong to ST131 (3,4). Population genetics indicate that ST131 consists of different clades (5): clade A contains serotype O16:H5 and fimH41, clade B contains mostly serotype O25b:H4 and fimH22, and clade C contains serotype O25b:H4 and fimH30. Clade C is divided into 2 subclades: C1/H30R (associated with fluoroquinolone resistance) and C2/H30Rx (associated with fluoroquinolone resistance and bla CTX-M-15 ). A novel ST131 C1 subclade, known as C1-M27 with bla CTX-M-27 , was reported in Japan (6).