Mechanistic and biological characterisation of novel<i>N</i><sup>5</sup>-substituted paullones targeting the biosynthesis of trypanothione in<i>Leishmania</i>
Andrea Medeiros, Diego Benítez, Ricarda S. Korn, Vinicius C. Ferreira, Exequiel Barrera, Federico Carrión, Otto Pritsch, Sergio Pantano, Conrad Kunick, Camila I. de Oliveira, Oliver C. F. Orban, Marcelo A. Comini
Abstract
species.
Topics & Concepts
Leishmania braziliensisLeishmaniaBiochemistrySpermidineChemistryLeishmania infantumBiologyStereochemistryTrypanosoma bruceiLeishmaniasisEnzymeGeneVisceral leishmaniasisGeneticsCutaneous leishmaniasisWorld Wide WebParasite hostingComputer scienceResearch on Leishmaniasis StudiesTrypanosoma species research and implicationsPhenothiazines and Benzothiazines Synthesis and Activities