A system for the high-throughput measurement of the shear modulus distribution of human red blood cells
Amir Saadat, Diego A. Huyke, Diego I. Oyarzun, Paulina V. Escobar, Ingrid H. Øvreeide, Eric S. G. Shaqfeh, Juan G. Santiago
Abstract
cell velocities. The combination of modeling, microfluidics, and imaging enables, for the first time, quantitative measurement of the shear moduli of thousands of RBCs in human blood samples. We demonstrate the high-throughput features by sensitive quantification of the changes in the distribution of RBC stiffness with aging. This combined measurement and computational platform is ultimately intended to diagnose blood cell disorders in patients.
Topics & Concepts
Shear modulusMeasure (data warehouse)MicrofluidicsHuman bloodModulusShear (geology)Materials scienceThroughputBiomedical engineeringNanotechnologyBiological systemComposite materialComputer scienceEngineeringBiologyData miningTelecommunicationsPhysiologyWirelessBlood properties and coagulationErythrocyte Function and PathophysiologyMicrofluidic and Bio-sensing Technologies