DNA Methyltransferase Regulates Nitric Oxide Homeostasis and Virulence in a Chronically Adapted Pseudomonas aeruginosa Strain
Shuhong Han, Jihong Liu, Mianhuan Li, Yizhou Zhang, Xiangke Duan, Yingdan Zhang, Hao Chen, Zhao Cai, Liang Yang, Yang Liu
Abstract
analysis suggested that DNA methylation modification may enhance gene expression by affecting the binding of transacting factors such as DNR and RpoN. Our findings not only deepen the understanding of the role of DNA MTase in transcriptional regulation in P. aeruginosa but also provide a theoretical foundation for the in-depth study of the molecular mechanism of the epigenetic regulation on denitrification, virulence, and host-pathogen interaction.
Topics & Concepts
BiologyPseudomonas aeruginosaVirulenceDNA methylationMethylationMicrobiologyMethyltransferaseEpigeneticsGeneticsMutantGeneGene expressionBacteriaEpigenetics and DNA MethylationMicrobial Community Ecology and PhysiologyVibrio bacteria research studies