Management of Cannabinoid Hyperemesis Syndrome: Focus on Capsaicin
Janice L. Stumpf, Lauren D. Williams
Abstract
Cannabinoid hyperemesis syndrome is a condition characterized by cyclic severe nausea, vomiting, and abdominal pain associated with frequent, long-term marijuana use. The condition resolves with cessation of cannabis but may be temporarily relieved by bathing in hot water. Topical capsaicin cream may also alleviate symptoms, perhaps through antiemetic effects produced by activation of TRPV1 receptors, similar to that of hot water bathing. This review summarizes the epidemiology, clinical presentation, diagnosis, pathophysiology, and management of cannabinoid hyperemesis syndrome, focusing on treatment with topical capsaicin.
Topics & Concepts
MedicineBathingNauseaCapsaicinAntiemeticVomitingCannabinoid receptorCannabisAnesthesiaAbdominal painCannabinoidMidodrineIntensive care medicineInternal medicinePsychiatryReceptorPathologyBlood pressureAgonistOrthostatic vital signsCannabis and Cannabinoid ResearchPoisoning and overdose treatmentsRespiratory and Cough-Related Research