Electrosynthesis of Spiro-indolenines via Dearomative Arylation of Indoles in Batch and Continuous Flow
Wei Zhao, Yi Lu, Yaqi Qiao, Xing Yin, Chengkou Liu, Zheng Fang, Jianliang Zhu, Kai Guo
Abstract
An electrosynthesis of spiro-indolenines in batch and continuous flow was achieved through dearomative arylation of indoles with good functional group compatibility. User-friendly undivided cells were used under catalyst- and oxidant-free conditions. Moreover, the use of a flow electrolysis cell gave high daily productivity and excellent scale-up potential under less supporting electrolyte and higher substrate concentration conditions.
Topics & Concepts
ElectrosynthesisElectrolysisChemistryContinuous flowBatch processingElectrolyteCatalysisSubstrate (aquarium)Combinatorial chemistryFlow chemistryChemical engineeringOrganic chemistryElectrochemistryBiochemical engineeringComputer scienceElectrodePhysical chemistryEngineeringGeologyProgramming languageOceanographyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques