Development of a thermochromic lateral flow assay to improve sensitivity for dengue virus serotype 2 NS1 detection
Thithawat Trakoolwilaiwan, Yasuhiro Takeuchi, Terence S. Leung, Matej Sebek, Liudmyla Storozhuk, Nguyen Thuy Ba Linh, Le Duc Tung, Nguyễn Thị Kim Thanh
Abstract
. The colorimetric thermal sensing LFA is capable of reducing the limit of detection (LOD) of DENV2-NS1 by 4 times compared to the typical visual readout. The colorimetric thermal sensing LFA can enhance the sensitivity of detection and deliver visuality to the user to translate without the need for an infrared (IR) camera. It has the potential to expand the utilities of LFA and satisfy early diagnostic applications.
Topics & Concepts
Dengue virusSerotypeDengue feverVirologyThermochromismDetection limitVirusRecombinant DNAChemistryBiologyChromatographyBiochemistryOrganic chemistryGeneMosquito-borne diseases and controlMalaria Research and ControlViral Infections and Vectors