Thieno[2,3-<i>d</i>]pyrimidine-2,4(1<i>H</i>,3<i>H</i>)-dione Derivative Inhibits <scp>d</scp>-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells
Zhangping Xiao, Angelina Osipyan, Shanshan Song, Deng Chen, Reinder A. Schut, Ronald van Merkerk, Petra E. van der Wouden, Robbert H. Cool, Wim J. Quax, Barbro N. Melgert, Gerrit J. Poelarends, Frank J. Dekker
Abstract
) with improved antiproliferative activity in cellular models systems, which indicates the potential of targeting MIF2 in cancer treatment.
Topics & Concepts
ChemistryMacrophage migration inhibitory factorCell growthMAPK/ERK pathwayBiochemistryKinaseCell biologyCytokineBiologyImmunologyMacrophage Migration Inhibitory Factor