Microwave-mediated stereocontrolled annulations of diazo(aryl)methyl(diaryl)phosphine oxides with pyridinium 1,4-zwitterionic thiolates
Simin Sun, Yuliang Wei, Jiaxi Xu
Abstract
([1+5]-1) annulation with P-Cope elimination as the key step. The annuloselectivity was controlled by the steric hindrance of pyridiniums in pyridinium 1,4-zwitterionic thiolates.
Topics & Concepts
PyridiniumChemistryAnnulationPhosphineDiazoSteric effectsIndolizineArylMedicinal chemistryBromideOrganic chemistryCatalysisAlkylCyclopropane Reaction MechanismsSynthesis and Reactivity of HeterocyclesCatalytic C–H Functionalization Methods