Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections
Hang Xu, Zhong-zuo Yan, Mengbi Guo, Ran An, Xin Wang, Rui Zhang, Yanhua Mou, Zhuang Hou, Chun Guo
Topics & Concepts
MiconazoleChemistryCandida albicansHemolysisPharmacologyIn vivoCorpus albicansSeleniumAntifungalMicrobiologyBiologyMedicineOrganic chemistryBiotechnologyInternal medicineAntifungal resistance and susceptibilitySynthesis and Biological EvaluationPhytochemical compounds biological activities