C–H functionalization through benzylic deprotonation with π-coordination or cation–π-interactions
Hui Zhu, Yu Wu, Jianyou Mao, Jingkai Xu, Patrick J. Walsh, Hang Shi
Abstract
Transition-metals bind arene π-systems, removing e − density and acidifying benzylic C–H’s. Main group metals achieve this via cation–π interactions. Both interactions enable catalytic base-promoted selective C–H functionalization.
Topics & Concepts
DeprotonationSurface modificationChemistryCatalysisTransition metalCombinatorial chemistryBase (topology)Organic chemistryIonPhysical chemistryMathematicsMathematical analysisCatalytic C–H Functionalization MethodsOrganoboron and organosilicon chemistryCatalytic Cross-Coupling Reactions