Comparative Efficacy of the Novel Diarylquinoline TBAJ-587 and Bedaquiline against a Resistant <i>Rv0678</i> Mutant in a Mouse Model of Tuberculosis
Jian Xu, Paul J. Converse, Anna M. Upton, Khisimuzi Mdluli, Nader Fotouhi, Eric L. Nuermberger
Abstract
mutant, TBAJ-587 has greater efficacy against both strains than BDQ, whether alone or in combination with pretomanid and either linezolid or moxifloxacin and pyrazinamide. TBAJ-587 also reduced the emergence of resistance to diarylquinolines and pretomanid.
Topics & Concepts
BedaquilineTuberculosisLinezolidRegimenMedicinePharmacologyDrug resistanceDrug resistant tuberculosisMycobacterium tuberculosisBiologyMicrobiologyInternal medicinePathologyBacteriaGeneticsVancomycinStaphylococcus aureusTuberculosis Research and EpidemiologyCancer therapeutics and mechanismsPneumocystis jirovecii pneumonia detection and treatment