Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease
Masaya Araki, Yoshimi Nakagawa, Hodaka Saito, Yasunari Yamada, Song‐iee Han, Yuhei Mizunoe, Hiroshi Ohno, Takafumi Miyamoto, Motohiro Sekiya, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano
Abstract
Hepatocyte- and macrophage-specific SREBP-1a knockout mice were generated for the first time. This study reveals that SREBP-1a does not contribute to hepatic lipogenesis, but in either hepatocytes or macrophages distinctly controls the onset of pathological conditions in methionine- and choline-deficient diet-induced hepatitis.
Topics & Concepts
Nonalcoholic fatty liver diseaseLipogenesisCholineHepatocyteMethionineInternal medicineEndocrinologyFatty liverSterol regulatory element-binding proteinMacrophageKnockout mouseSteatosisBiologyMedicineCholesterolDiseaseLipid metabolismBiochemistrySterolIn vitroReceptorAmino acidLiver Disease Diagnosis and TreatmentCholesterol and Lipid MetabolismPeroxisome Proliferator-Activated Receptors