Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery
Wei Chen, Jacob Wainer, Si Won Ryoo, Xiaoyue Qi, Rong Chang, Jason Li, Seung Ho Lee, Seokkee Min, Adam Wentworth, Joy Collins, Siddartha Tamang, Keiko Ishida, Alison Hayward, Róbert Langer, Giovanni Traverso
Abstract
-[8-(2-hydroxybenzoyl) amino] caprylate along with semaglutide and demonstrate enhanced absorption in swine resistant to physical displacement in the gastric cavity. Meanwhile, we developed a targeted capsule system capable of deploying intact microneedle-containing systems. These systems stand to enable the delivery of a range of drugs through the generation and maintenance of a privileged region in the gastrointestinal tract.
Topics & Concepts
AdhesiveDrug deliveryMacromoleculeDelivery systemMaterials scienceBiomedical engineeringNanotechnologyMedicineChemistryLayer (electronics)BiochemistryAdvancements in Transdermal Drug DeliveryAdvanced Drug Delivery SystemsGlycosylation and Glycoproteins Research